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Overall, the beneficial effects of ROS include (a) changes in the conformation of cell receptors that increase virus/cell receptor binding affinity, (b) increased autophagy to repress inflammasome activation, (c) sensitization of cells to the intrinsic apoptotic pathway promoting virus release and spread, (d) targeting of proteins involved in the immune response favoring immune evasion mechanisms, and (e) direct ROS-mediated induction of mutations on the viral genomes increasing virulence (Figure 3)